NAD+

Description

NAD+ — Essential Coenzyme for Metabolic and Epigenetic Research

NAD+ (nicotinamide adenine dinucleotide, oxidized form) is a ubiquitous coenzyme present in all living cells that serves as an essential electron carrier in cellular metabolism and a critical substrate for multiple families of regulatory enzymes. As a research reagent, NAD+ is used extensively in biochemical assays, enzyme kinetics studies, and cell biology experiments investigating energy metabolism, DNA repair, gene expression regulation, and cellular aging. NAD+ functions as a substrate for sirtuins (SIRT1-7), a family of NAD+-dependent deacylase enzymes that regulate histone acetylation, transcription factor activity, and mitochondrial biogenesis.

Additionally, NAD+ serves as the substrate for poly(ADP-ribose) polymerases (PARPs), enzymes critical for DNA damage detection and repair signaling. Researchers studying the NAD+ metabolome, including the interconnected biosynthetic pathways involving nicotinamide, nicotinic acid, nicotinamide riboside, and nicotinamide mononucleotide, rely on exogenous NAD+ as both a reference standard and an experimental variable in their analytical workflows. In cell culture applications, NAD+ supplementation studies have been used to investigate effects of coenzyme availability on mitochondrial complex I activity, oxidative phosphorylation efficiency, and cellular resistance to metabolic stress.

Coffee & Pepper Peptides provides NAD+ as a high-purity research-grade reagent with complete analytical documentation. This product is intended exclusively for laboratory use and is not intended for human or animal consumption or dietary supplementation.

FDA DISCLAIMER

The information provided on this website has not been evaluated by the U.S. Food and Drug Administration (FDA). None of the statements herein, nor any of the products offered, are intended to diagnose, treat, cure, or prevent any medical condition.

All products are supplied strictly as laboratory research reagents and are not for human consumption. We do not provide products to patients and do not make any claims regarding medical use.

Coffee & Pepper Peptides operates solely as a chemical supplier. It is not a compounding pharmacy and does not operate as a compounding facility under Section 503A of the Federal Food, Drug, and Cosmetic Act.